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Applying one-molecule optical and AFM imaging and power-spectroscopy methods, we seek to unravel the mechanistic components of the framework and dynamics of chromosomes. Our study interests include things like:

1996, first mesoscopic charge density waves products; and first electrical measurements on an individual metallic nanocluster in between nanoelectrodes

‘It had been merely a matter of buying up a ebook on cell biology and starting to browse. I'd come from a environment of extremely-large vacuums, cryostats and quantum phenomena, and now I was Performing at area temperature with molecular biology kits.

Non-equilibrium folding of specific DNA molecules recaptured as many as one thousand moments in the reliable condition nanopore

2010, formulated a completely new way (‘wedging transfer’) to manipulate nanostructures; initial report of DNA translocation as a result of graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into stable-point out nanopores

SMC complexes can move physical roadblocks bigger than their ring sizing, indicating a nontopological system for DNA loop extrusion

Size control of personal carbon nanotubes by nanostructuring With all the scanning tunneling microscope

Case in point (1) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is demonstrated in gray, the rim on the pore is highlighted in red, cees dekker plus a 3D rendering from the movement from the DNA rod is shown.

‘Yes, I recognize people have been surprised at time. At the conclusion of the nineties, when I was in my forties, I used to be Professor of Molecular Electronics and I've to confess that it had turn into a little bit bored, I didn’t discover A great deal anymore. The sector went additional into the application aspect, how you could possibly integrate nanotubes into Digital circuits.

There was a single difficulty although — we didn't notice any measurable electrical conduction from the single polymer molecules. We concluded that at The one-molecule degree, conducting polymers were truly not this kind of fantastic conductors, which was instead disappointing. We thus broadened our look at to try to uncover a lot more promising molecules.

An built-in microfluidic System for quantifying drug permeation across biomimetic vesicle membranes

‘That worries the artificial cell, as Component of the Dutch BaSyC initiative. Craig Venter looked prime-down in those days and determined about five hundred genes which might be minimally required for the performing cell. We want to glance bottom-up: how do we go from the couple of molecules to a whole Organic program?

Visualization of unstained DNA nanostructures with State-of-the-art in-focus transmission electron microscopy methods

The biophysicist from Delft – who has long been One of the more cited experts while in the Netherlands For a long time – will take his duty to contribute to the rationalization and popularisation of his operate with the border of physics and biology incredibly critically and regularly seems while in the media; if not to take a look at his get the job done, then about the relationship between science and his Christian religion.